Defining Gene Transfer Before Expecting Gene Therapy

Defining gene transfer before expecting gene therapy: putting the horse before the cart.

The remarkable advances in our understanding of the molecular and biochemical bases for disease during the past decade, in conjunction with the “genomic revolution,” have generated understandable enthusiasm for the development of genetic therapies. Whereas the initial hope was that gene therapy would aid in the treatment of patients with primary genetic disorders, applications have now been exp...

Gene Transfer and Gene Therapy

however, suffer from a problem implied by its title. Dr. Schull's attempts to make the book lyrical lead to the sin of vivid writing, often complicated by inappropriate usages. For example, it seems unlikely that the lanes mentioned on page 15 were "tortured"; "tortuous" is more likely. Can sleep come in "dollops" (page 22)? Do physicians actually ride jeeps like "marauding bees" (page 26)? (Ar...

Anticancer gene transfer for cancer gene therapy.

Gene therapy vectors are among the treatments currently used to treat malignant tumors. Gene therapy vectors use a specific therapeutic transgene that causes death in cancer cells. In early attempts at gene therapy, therapeutic transgenes were driven by non-specific vectors which induced toxicity to normal cells in addition to the cancer cells. Recently, novel cancer specific viral vectors have...

Gene therapy for arthritis: defining novel gene targets

ژن درمانی Gene Therapy